Xyrem, a drug used to treat narcolepsy patients for muscle weakness and daytime sleepiness, can lead to unconsciousness, coma and even death when used in conjunction with alcohol or other depressant drugs warns the FDA. Specifically, the FDA warns that patients taking Xyrem should not drink alcohol or take insomnia drugs. Doing so can lead to breathing problems resulting in the loss of consciousness, coma or death. Also the following types of drugs should generally be avoided:
- opioid analgesics
- sedating antidepressants or antipsychotics
- general anesthetics
- muscle relaxants
Other side effects of Xyrem, even at regular, recommended doses without the use of alcohol or other drugs, include depression, confusion and other neuropsychiatric events. More information is available here.